Reversible Collapse of Rabbit Ears after Intravenous Papain, and Prevention of Recovery by Cortisone

@article{Thomas1956ReversibleCO,
  title={Reversible Collapse of Rabbit Ears after Intravenous Papain, and Prevention of Recovery by Cortisone},
  author={Lewis Thomas},
  journal={The Journal of Experimental Medicine},
  year={1956},
  volume={104},
  pages={245 - 252}
}
  • Lewis Thomas
  • Published 1956 in The Journal of experimental medicine
A substance has been demonstrated in solutions of crude papain, which, when injected intravenously into 1 kilo rabbits, in amounts less than 5 mg., results in complete collapse of both ears. The phenomenon becomes visible 4 hours after injection, and is complete within 24 hours. 3 or 4 days after papain, the ears gradually reassume their normal form. Ear collapse is associated with depletion of the ear cartilage matrix, and the disappearance of basophilia from the matrix. Similar changes occur… CONTINUE READING
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Connective Tissues, Josiah

  • G. Asboe-Hansen, Tr
  • 1954

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