Reversible Binding of Long-chain Fatty Acids to Purified FAT, the Adipose CD36 Homolog

@article{Baillie1996ReversibleBO,
  title={Reversible Binding of Long-chain Fatty Acids to Purified FAT, the Adipose CD36 Homolog},
  author={A G Baillie and Chris T. Coburn and Nada A. Abumrad},
  journal={The Journal of Membrane Biology},
  year={1996},
  volume={153},
  pages={75-81}
}
Transport of long-chain fatty acids into rat adipocytes was previously shown to be inhibited by the reactive derivative sulfosuccinimidyl oleate consequent to its binding to a membrane protein FAT, which is homologous to CD36. In this report, the ability of the purified protein to bind native fatty acids was investigated. CD36 was isolated from rat adipocytes by phase partitioning into Triton X-114 followed by chromatography on DEAE and then on wheat germ agglutinin. Fatty acid binding was… CONTINUE READING
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