Reversible, activity-dependent targeting of profilin to neuronal nuclei.

  title={Reversible, activity-dependent targeting of profilin to neuronal nuclei.},
  author={Andreas Birbach and Jan Martin Verkuyl and Aurora Matus},
  journal={Experimental cell research},
  volume={312 12},
The actin cytoskeleton in pyramidal neurons plays a major role in activity-dependent processes underlying neuronal plasticity. The small actin-binding protein profilin shows NMDA receptor-dependent accumulation in dendritic spines, which is correlated with suppression of actin dynamics and long-term stabilization of synaptic morphology. Here we show that following NMDA receptor activation profilin also accumulates in the nucleus of hippocampal neurons via a process involving rearrangement of… CONTINUE READING


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