Reversibility of structural and functional damage in a model of advanced diabetic nephropathy.

@article{Pichaiwong2013ReversibilityOS,
  title={Reversibility of structural and functional damage in a model of advanced diabetic nephropathy.},
  author={Warangkana Pichaiwong and Kelly L. Hudkins and T. Wietecha and Tri Quang Nguyen and Chiraporn Tachaudomdach and Wei Li and Bardia Askari and Takahisa Kobayashi and Kevin D O'brien and Jeffrey W. Pippin and Stuart J. Shankland and Charles E. Alpers},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2013},
  volume={24 7},
  pages={1088-102}
}
The reversibility of diabetic nephropathy remains controversial. Here, we tested whether replacing leptin could reverse the advanced diabetic nephropathy modeled by the leptin-deficient BTBR ob/ob mouse. Leptin replacement, but not inhibition of the renin-angiotensin-aldosterone system (RAAS), resulted in near-complete reversal of both structural (mesangial matrix expansion, mesangiolysis, basement membrane thickening, podocyte loss) and functional (proteinuria, accumulation of reactive oxygen… CONTINUE READING