Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling.

@article{Jo2009ReversibilityOE,
  title={Reversibility of epithelial-mesenchymal transition (EMT) induced in breast cancer cells by activation of urokinase receptor-dependent cell signaling.},
  author={Minji Jo and Robin D. Lester and Val{\'e}rie Montel and Boryana M Eastman and S. Takimoto and Steven L Gonias},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 34},
  pages={
          22825-33
        }
}
Hypoxia induces expression of the urokinase receptor (uPAR) and activates uPAR-dependent cell signaling in cancer cells. This process promotes epithelial-mesenchymal transition (EMT). uPAR overexpression in cancer cells also promotes EMT. In this study, we tested whether uPAR may be targeted to reverse cancer cell EMT. When MDA-MB 468 breast cancer cells were cultured in 1% O(2), uPAR expression increased, as anticipated. Cell-cell junctions were disrupted, vimentin expression increased, and E… CONTINUE READING

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