Reversibility of beta-amyloid self-assembly: effects of pH and added salts assessed by fluorescence photobleaching recovery.

@article{Edwin2010ReversibilityOB,
  title={Reversibility of beta-amyloid self-assembly: effects of pH and added salts assessed by fluorescence photobleaching recovery.},
  author={Nadia J Edwin and Robert P. Hammer and Robin L McCarley and Paul S Russo},
  journal={Biomacromolecules},
  year={2010},
  volume={11 2},
  pages={341-7}
}
The 40-residue peptide isoform beta-amyloid (Abeta(1-40)) is associated with Alzheimer's disease. Although found in the tangles and fibrous mats that characterize the brain in advanced stages of the disease, the toxic form of Abeta is believed to be oligomers or "protofibrils". Characterization of these fairly small structures in solution, especially in the presence of the much larger assemblies they also form, is a daunting task. Additionally, little is known about the rate of Abeta assembly… CONTINUE READING
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Elucidating the Kinetics of  - Amyloid Fibril Formation

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Fluorescence Photobleaching Recovery , a Primer

  • P. S. Russo, J. Qiu, N. Edwin, Y.-W. Choi, G. Doucet, D. Sohn
  • Soft - Matter Characterization

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