Reversibility of IgE-mediated rat mast cell desensitization.

  title={Reversibility of IgE-mediated rat mast cell desensitization.},
  author={Guillermo Roberto Mendoza and Francine B. Orner},
  journal={International archives of allergy and applied immunology},
  volume={69 1},
Desensitization in normal rat peritoneal mast cells was induced by subthreshold and suboptimal levels of antirat IgE under normal calcium buffer conditions. Low doses of anti-IgE which triggered 0-10% net histamine release, initiated up to 100% desensitization. The rate of desensitization was highly variable in different rats, resulting in an irregular decay of releasability over the first 30 min. After 120-150 min of desensitization, rat mast cells in 3 of 5 experiments spontaneously regained… CONTINUE READING