Reversibility in nucleocytoplasmic transport.

@article{Kopito2007ReversibilityIN,
  title={Reversibility in nucleocytoplasmic transport.},
  author={Ronen Benjamine Kopito and Michael Elbaum},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 31},
  pages={
          12743-8
        }
}
Nucleocytoplasmic exchange of proteins and RNAs is mediated by receptors that usher their cargo through the nuclear pores. Peptide localization signals on each cargo determine the receptors with which it will interact. Those interactions are normally regulated by the small GTPase Ran. Hydrolysis of GTP provides the chemical energy required to create a bona fide thermodynamic pump that selectively and directionally accumulates its substrates across the nuclear envelope. A common perception is… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 29 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-4 OF 4 REFERENCES

Methods Mol Biol

  • RC Chan, DI Forbes
  • 2006

C R Biol

  • C Fradin, D Zbaida, M Elbaum
  • 2005

Methods Cell Biol

  • DD Newmeyer, KL Wilson
  • 1991

Methods Enzymol 171:23–62

  • WD Stein
  • 1989
1 Excerpt

Similar Papers

Loading similar papers…