Reversed-phase high-performance liquid chromatographic enantioresolution of six beta-blockers using dinitrophenyl-L-Pro-N-hydroxysuccinimide ester, N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate and twelve variants of Sanger's reagent as chiral derivatizing reagents.

@article{Bhushan2009ReversedphaseHL,
  title={Reversed-phase high-performance liquid chromatographic enantioresolution of six beta-blockers using dinitrophenyl-L-Pro-N-hydroxysuccinimide ester, N-succinimidyl-(S)-2-(6-methoxynaphth-2-yl) propionate and twelve variants of Sanger's reagent as chiral derivatizing reagents.},
  author={R. Bhushan and Shivani Tanwar},
  journal={Biomedical chromatography : BMC},
  year={2009},
  volume={23 12},
  pages={
          1291-9
        }
}
  • R. Bhushan, Shivani Tanwar
  • Published 2009
  • Chemistry, Medicine
  • Biomedical chromatography : BMC
  • Twelve chiral derivatizing reagents (CDRs) were synthesized by substituting one of the fluorine atoms in 1,5-difluoro-2,4-dinitrobenzene (DFDNB) with three optically pure amines [(R)-(-)-1-cyclohexylethylamine, (+)-dehydroabietylamine and (S)-(-)-alpha,4-dimethylbenzylamine], six amino acid amides [L-Ala-NH(2), L-Phe-NH(2), L-Val-NH(2), L-Leu-NH(2), L-Met-NH(2) and D-Phg-NH(2)] and three amino acids [L-Ala, L-Val and L-Leu]. In addition, dinitrophenyl-L-Pro-N-hydroxysuccinimide ester and N… CONTINUE READING
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    References

    SHOWING 1-10 OF 46 REFERENCES
    Determination ofD-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene
    • 999
    • PDF
    Reversed-phase high-performance liquid chromatographic analysis of atenolol enantiomers in rat hepatic microsome after chiral derivatizaton with 2,3,4,6,-tetra-O-acetyl-beta-D-glycopyranosyl isothiocyanate.
    • X. Li, T. Yao, S. Zeng
    • Chemistry, Medicine
    • Journal of chromatography. B, Biomedical sciences and applications
    • 2000
    • 17