Reversed-phase high-performance liquid chromatography of ketorolac and its application to bioequivalence studies in human serum.

@article{Chaudhary1993ReversedphaseHL,
  title={Reversed-phase high-performance liquid chromatography of ketorolac and its application to bioequivalence studies in human serum.},
  author={Rakesh Singh Chaudhary and Sanjay Gangwal and Kaur Chand Jindal and Savita Khanna},
  journal={Journal of chromatography},
  year={1993},
  volume={614 1},
  pages={
          180-4
        }
}
A reversed-phase high-performance liquid chromatographic assay was used to study the bioequivalence of the anti-inflammatory drug (+/-)-ketorolac in human volunteers. Following deproteinization of human serum with 5% zinc sulphate solution, ketorolac was chromatographed on a 10-microns octadecylsilica column using acetonitrile-water as mobile phase and ultraviolet detection at 313 nm. Under these conditions the method was reproducible with a coefficient of variation of less than 5%. The assay… CONTINUE READING

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