Reversed-phase HPLC separation of plasma norepinephrine, epinephrine, and dopamine, with three-electrode coulometric detection.

@article{Musso1989ReversedphaseHS,
  title={Reversed-phase HPLC separation of plasma norepinephrine, epinephrine, and dopamine, with three-electrode coulometric detection.},
  author={Natale R. Musso and C Vergassola and Aldo Pende and Gaetano Lotti},
  journal={Clinical chemistry},
  year={1989},
  volume={35 9},
  pages={
          1975-7
        }
}
We present a method involving minor modifications of previous techniques, in which we use an ion-pair reversed-phase HPLC separation with three-electrode coulometry. Isocratic baseline separations can be obtained in 5 min. The sample preparation procedure, involving extraction with alumina at low temperature, allows good reproducibility (within-run and between-run CVs less than 10%) and improved sensitivity (less than 5 pg of each catecholamine per extract). This method allows approximately 70… CONTINUE READING
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