Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells

@inproceedings{Zheng2013ReversedAL,
  title={Reversed argininosuccinate lyase activity in fumarate hydratase-deficient cancer cells},
  author={Liang Zheng and E. D. Mackenzie and Saadia A. Karim and Ann Hedley and Karen Blyth and Gabriela Kalna and David G Watson and Peter Wojciech Szlosarek and Christian Frezza and Eyal Gottlieb},
  booktitle={Cancer & metabolism},
  year={2013}
}
BACKGROUND Loss of function of fumarate hydratase (FH), the mitochondrial tumor suppressor and tricarboxylic acid (TCA) cycle enzyme, is associated with a highly malignant form of papillary and collecting duct renal cell cancer. The accumulation of fumarate in these cells has been linked to the tumorigenic process. However, little is known about the overall effects of the loss of FH on cellular metabolism. METHODS We performed comprehensive metabolomic analyses of urine from Fh1-deficient… CONTINUE READING