Reversed-Phase UHPLC Enantiomeric Separation of Rasagiline Salts Using a Chiralpak® AGP Column

@article{Balaji2017ReversedPhaseUE,
  title={Reversed-Phase UHPLC Enantiomeric Separation of Rasagiline Salts Using a Chiralpak{\textregistered} AGP Column},
  author={Nagarajan Balaji and Sayeeda Sultana},
  journal={Scientia Pharmaceutica},
  year={2017},
  volume={85}
}
We report the first rapid ultra-high performance liquid chromatographic (UHPLC) enantiomeric reversed-phase separation of rasagiline mesylate and its tartrate salts using a Chiralpak® AGP column (50 mm × 2.1 mm, 5 μm) as a stationary phase. This method was developed as an alternative to the usage of previously reported normal-phase chiral LC columns for isomer separation. Our method is based on an isocratic approach using a mixture of ammonium acetate and isopropyl alcohol (90:10, v/v) as the… 
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