Reversed Phase High Presssure Liquid Chromatograhphic Technique for Determination of Sodium Alginate from Oral Suspension

  • Warkar C . B . D . G . Ruparel
  • Published 2003

Abstract

Rapid and accurate high performance liquid chromatography method is described for determination of Sodium alginate from the oral suspension. The separation of drug was achieved on Primecep C (150 x 4.6 mm i.d.) 5μ column. The mobile phase consisted of 40 milli molar anhydrous dibasic sodium phosphate with the pH of the solution adjusted to 6.0 with dilute sodium hydroxide. The detection was carried out at wavelength 210 nm. The Primecep C column showed the most favorable chromatographic parameters for analysis. The method was validated for System suitability, linearity, accuracy, precision, robustness and stability of sample solution. The linear range for sodium alginate was 206.9 – 620.9 μg/ml. The method has been successfully used to analyze commercial oral suspension containing sodium alginate with good recovery.

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Cite this paper

@inproceedings{Ruparel2003ReversedPH, title={Reversed Phase High Presssure Liquid Chromatograhphic Technique for Determination of Sodium Alginate from Oral Suspension}, author={Warkar C . B . D . G . Ruparel}, year={2003} }