Reverse transcription of the HIV‐1 pandemic
@article{Basavapathruni2007ReverseTO, title={Reverse transcription of the HIV‐1 pandemic}, author={A. Basavapathruni and K. Anderson}, journal={The FASEB Journal}, year={2007}, volume={21}, pages={3795 - 3808} }
The HIV/AIDS pandemic has existed for >25 years. Extensive work globally has provided avenues to combat viral infection, but the disease continues to rage on in the human population and infected ~4 million people in 2006 alone. In this review, we provide a brief history of HIV/AIDS, followed by analysis of one therapeutic target of HIV‐1: its reverse transcriptase (RT). We discuss the biochemical characterization of RT in order to place emphasis on possible avenues of inhibition, which now… Expand
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