Reverse transcription of the HIV‐1 pandemic

  title={Reverse transcription of the HIV‐1 pandemic},
  author={A. Basavapathruni and K. Anderson},
  journal={The FASEB Journal},
  pages={3795 - 3808}
The HIV/AIDS pandemic has existed for >25 years. Extensive work globally has provided avenues to combat viral infection, but the disease continues to rage on in the human population and infected ~4 million people in 2006 alone. In this review, we provide a brief history of HIV/AIDS, followed by analysis of one therapeutic target of HIV‐1: its reverse transcriptase (RT). We discuss the biochemical characterization of RT in order to place emphasis on possible avenues of inhibition, which now… Expand
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