Reverse remodeling of cardiac myocyte hypertrophy in hypertension and failure by targeting of the renin-angiotensin system.

@article{Tamura2000ReverseRO,
  title={Reverse remodeling of cardiac myocyte hypertrophy in hypertension and failure by targeting of the renin-angiotensin system.},
  author={Tetsutaro Tamura and Suleman Said and J. Harris and Wei Lu and Anthony Martin Gerdes},
  journal={Circulation},
  year={2000},
  volume={102 2},
  pages={
          253-9
        }
}
BACKGROUND ACE inhibitors (ACEIs) and angiotensin II type 1 (AT(1)) receptor blockers are effective in reducing left ventricular mass in hypertension and heart failure. However, the ability of these drugs to reverse excessive myocyte lengthening and transverse growth in heart failure is unknown. METHODS AND RESULTS L-158,809 (an AT(1) blocker; AT(1)), enalapril (an ACEI), and hydralazine (a vasodilator) were administered to spontaneously hypertensive heart failure rats between 6 and 10 months… 

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