Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations

Abstract

Class III antiarrhythmic agents exhibit reverse rate-dependent lengthening of the action potential duration (APD). In spite of the several theories developed so far to explain this reverse rate-dependency (RRD), its mechanism has not yet been clarified. The aim of the present work was to further elucidate the mechanisms responsible for RRD in mammalian… (More)
DOI: 10.1007/s00395-009-0082-7

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@article{Brndi2009ReverseRC, title={Reverse rate-dependent changes are determined by baseline action potential duration in mammalian and human ventricular preparations}, author={L{\'a}szl{\'o} B{\'a}r{\'a}ndi and L{\'a}szl{\'o} Vir{\'a}g and Norbert Jost and Zolt{\'a}n Horv{\'a}th and Istv{\'a}n Koncz and Rita Papp and G{\'a}bor Harmati and Balazs Horvath and Norbert Szentandr{\'a}ssy and Tam{\'a}s B{\'a}ny{\'a}sz and J{\'a}nos Magyar and Antonio Zaza and Andr{\'a}s Varr{\'o} and P{\'e}ter P{\'a}l N{\'a}n{\'a}si}, journal={Basic Research in Cardiology}, year={2009}, volume={105}, pages={315-323} }