Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation.

@article{Gouix2009ReverseGG,
  title={Reverse glial glutamate uptake triggers neuronal cell death through extrasynaptic NMDA receptor activation.},
  author={E Gouix and Fr{\'e}d{\'e}ric L{\'e}veill{\'e} and Olivier Nicole and Christophe Melon and Laurence Had-Aissouni and Alain Buisson},
  journal={Molecular and cellular neurosciences},
  year={2009},
  volume={40 4},
  pages={463-73}
}
Evidence have accumulated that reverse glutamate uptake plays a key role in the pathophysiology of cerebral ischemia. Here, we investigated the effects of glial glutamate transporter dysfunction on neuronal survival using the substrate inhibitor of glutamate transporters, L-trans-pyrrolidine,2-4,dicarboxylate (PDC), that partly mimics reverse glutamate uptake. On mice primary cortical co-cultures of neurons and astrocytes, PDC treatment triggered an elevation of extracellular glutamate… CONTINUE READING
35 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

Similar Papers

Loading similar papers…