Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?

  title={Reverse geroscience: how does exposure to early diseases accelerate the age‐related decline in health?},
  author={Ronald Kohanski and Steven G. Deeks and Claudia Gravekamp and Jeffrey B. Halter and Kevin P. High and Arti Hurria and Rebecca A. Fuldner and Paige Green and Robin E. Huebner and Francesca Macchiarini and Felipe Sierra},
  journal={Annals of the New York Academy of Sciences},
Aging is the major risk factor for both the development of chronic diseases and loss of functional capacity. Geroscience provides links among the biology of aging, the biology of disease, and the physiology of frailty, three fields where enormous progress has been made in the last few decades. While, previously, the focus was on the role of aging in susceptibility to disease and disability, the other side of this relationship, which is the contribution of disease to aging, has been less… 

Moving geroscience from the bench to clinical care and health policy

The emergence of biological aging as one the most important modifiable factors of COVID-19, combined with the inability of the authors' society to once again recognize and confront aging as a priority and opportunity when facing these types of public health emergencies are combined.

Aging Research: Collaborations Forge a Promising Future

Several highlights of multiple fruitful research collaborations within and outside the federal government, spanning the breadth of the Institute's research activities, have marked NIA's growth over the past 40 years, as well as its current areas of ongoing research.

Integrative biomarkers of biologic aging in HIV.

This data suggests that fundamental cellular and molecular pathways common to the aging process may be altered as a function of the disease or its treatment and understanding this interaction may help alter the trajectory of aging in individuals.

Integrating Environment and Aging Research: Opportunities for Synergy and Acceleration

This scoping review aims to highlight overlaps and gaps in existing knowledge and identify essential research initiatives to improve policy, reduce disparities, and enhance the quality of life for older individuals.

Ageing with HIV: health implications and evolving care needs

This model establishes a unique framework to measure individualized health in PLWH who experience an increased lifespan with antiretroviral therapy, but not necessarily in their “healthspan” [6].

Translational research in the fastest-growing population: older adults

Premature Aging in Young Cancer Survivors.

Emerging evidence suggests that cancer survivors are at risk for premature aging, manifesting as early onset of chronic health conditions and a higher risk of mortality compared with the general population.

Multimorbidity and functional impairment–bidirectional interplay, synergistic effects and common pathways

Identifying modifiable risk factors and pathways common to multimorbidity and functional impairment could aid in the design of interventions to delay, prevent or alleviate age‐related health deterioration; this review provides an overview of knowledge gaps and future directions.

Is an MRI-derived anatomical measure of dementia risk also a measure of brain aging?

Machine learning methods have been applied to estimate measures of brain aging from neuroimages. However, only rarely have these measures been examined in the context of biologic age. Here, we

Aging Accelerates Postural Instability in HIV Infection: Contributing Sensory Biomarkers.

Sway paths were disproportionately longer for PWH than PWoH when tested with eyes closed than open, whereas age, sway path length, and self-reports of falls were predictors of standing on one leg, a common measure of ataxia.



Advances in geroscience: impact on healthspan and chronic disease.

With the proportion of older people among the global population being now higher than at any time in history and still expanding, maintaining health into old age (or healthspan) has become a new and urgent frontier for modern medicine.

The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?

The National Institute on Aging’s Interventions Testing Program has been phenomenally successful at discovering compounds that extend life in genetically heterogeneous mice, suggesting the real possibility that successful interventions in the aging process can be developed for humans.

The intersection between aging and cardiovascular disease.

Some of the key genes involved in regulating lifespan and health span, including sirtuins, AMP-activated protein kinase, mammalian target of rapamycin, and insulin-like growth factor 1 and their roles regulating cardiovascular health are provided.

Disease drivers of aging

The impact of three chronic diseases and their treatments on aging, putative mechanisms by which these effects are mediated, and the open questions and future research directions required to understand the relationships between these diseases and aging are discussed.

HIV and Aging: Parallels and Synergistic Mechanisms Leading to Premature Disease and Functional Decline

It is still unclear whether HIV-associated ‘aging’ is truly due to acceleration of the aging process or whether HIV is a risk factor for multiple diseases leading to the “aged phenotype” at a younger age, but uncovering the critical processes which drive age-related changes and identifying therapeutic strategies to ameliorate them will be important for management of PAWH.

Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases.

  • C. FranceschiJ. Campisi
  • Medicine, Biology
    The journals of gerontology. Series A, Biological sciences and medical sciences
  • 2014
The session on inflammation of the Advances in Gerosciences meeting held at the National Institutes of Health/National Institute on Aging in Bethesda on October 30 and 31, 2013 was aimed at defining these important unanswered questions about inflammaging.

Exercise attenuates the premature cardiovascular aging effects of type 2 diabetes mellitus

The exercise-focused perspective for this review is appropriate because impairments in exercise performance are markers of premature cardiovascular aging in T2D, and also because exercise training shows promise to attenuate some aspects of cardiovascular aging during the preclinical stage.

Mechanisms of development of multimorbidity in the elderly

  • P. Barnes
  • Biology, Medicine
    European Respiratory Journal
  • 2015
Common disease pathways, particularly accelerated ageing, should be targeted and COPD should be considered as a component of multimorbidity and this area of research should be given high priority.

The Critical Role of Metabolic Pathways in Aging

A special focus is made in this study on healthspan, as improved quality of life is the goal when translated to humans, and recent advances in the understanding of the complex role of metabolic pathways in the aging process are discussed.