Reverse genetics system for the avian coronavirus infectious bronchitis virus.

  title={Reverse genetics system for the avian coronavirus infectious bronchitis virus.},
  author={R C B Casais and Volker Thiel and Stuart G. Siddell and David Cavanagh and Paul Britton},
  journal={Journal of virology},
  volume={75 24},
Major advances in the study of the molecular biology of RNA viruses have resulted from the ability to generate and manipulate full-length genomic cDNAs of the viral genomes with the subsequent synthesis of infectious RNA for the generation of recombinant viruses. Coronaviruses have the largest RNA virus genomes and, together with genetic instability of some cDNA sequences in Escherichia coli, this has hampered the generation of a reverse-genetics system for this group of viruses. In this report… CONTINUE READING
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