Reverse genetics of influenza virus.

@article{Neumann2001ReverseGO,
  title={Reverse genetics of influenza virus.},
  author={Gabriele Neumann and Yoshihiro Kawaoka},
  journal={Virology},
  year={2001},
  volume={287 2},
  pages={
          243-50
        }
}
Reverse genetics of negative-sense RNA viruses, which enables one to generate virus entirely from cloned cDNA, has progressed rapidly over the past decade. However, despite the relative ease with which nonsegmented negative-sense RNA viruses can now be produced from plasmids, the ability to generate viruses with segmented genomes has lagged considerably, largely because of the inherent technical difficulties in providing all viral RNAs and proteins from cloned cDNA. A breakthrough in reverse… CONTINUE READING

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 34 CITATIONS

Live attenuated swine influenza vaccine by reverse genetics

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Promises and challenges of live-attenuated intranasal influenza vaccines across the age spectrum: A review

T. G. oyce, G. A. Poland
  • Biomed. Pharmacother
  • 2000
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Transcription antitermination during influenza viral template RNA synthesis requires the nucleocapsid protein and the absence of a 5' capped end.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1986
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

A DNA transfection system for generation of influenza A virus from eight plasmids.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2000
VIEW 1 EXCERPT

Establishment of a rescue system for canine distemper virus

U. assen, F. M. Collins, W. P. Duprex, B. K. Rima
  • J. Virol
  • 2000