Reverse engineering of gene regulatory networks: a finite state linear model

@article{Brazma2003ReverseEO,
  title={Reverse engineering of gene regulatory networks: a finite state linear model},
  author={Alvis Brazma and Thomas Schlitt},
  journal={Genome Biology},
  year={2003},
  volume={4},
  pages={1-31}
}
We propose a new model for describing gene regulatory networks that can capture discrete (Boolean) and continuous (differential) aspects of gene regulation. After giving some illustrations of the model, we study the problem of the reverse engineering of such networks, i.e., how to construct a network from gene expression data. We prove that for our model there exists an algorithm finding a network compatible with the given data. We demonstrate the model by simulating lambda-phage. We also… CONTINUE READING

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