Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway.

@article{Parker2004ReverseEO,
  title={Reverse endocytosis of transmembrane ephrin-B ligands via a clathrin-mediated pathway.},
  author={Monica A Parker and Richard Roberts and Miriam L Enriquez and Xia Zhao and Takamune Takahashi and Douglas Pat Cerretti and Tom Daniel and Jin Chen},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={323 1},
  pages={17-23}
}
Eph/ephrin receptors and ligands mediate cell-cell interaction through reciprocal signaling upon juxtacrine contact, and play a critical role in embryonic patterning, neuronal targeting, and vascular assembly. To study transmembrane ephrin-B ligand trafficking, we determined the cellular localization of ephrin-B1-GFP upon engagement by EphB1. Under normal culture conditions ephrin-B1-GFP is localized to the plasma membrane, mostly at the lateral cell borders. Addition of soluble EphB1-Fc… CONTINUE READING
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