Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.

@article{Feig1994ReverseCM,
  title={Reverse chemical mutagenesis: identification of the mutagenic lesions resulting from reactive oxygen species-mediated damage to DNA.},
  author={D I Feig and Lawrence C. Sowers and L. A. Loeb},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 14},
  pages={6609-13}
}
An understanding of the contribution of reactive oxygen species to mutagenesis has been hampered by the vast number of different chemical modifications they cause in DNA. Even though many of these DNA alterations have been catalogued, the identification of specific lesions that cause mutations has depended on testing one modification at a time. In this… CONTINUE READING