Reverse Engineering the Yeast RNR1 Transcriptional Control System

  title={Reverse Engineering the Yeast RNR1 Transcriptional Control System},
  author={Grace Mao and James P. Brody},
  booktitle={PloS one},
Transcription is controlled by multi-protein complexes binding to short non-coding regions of genomic DNA. These complexes interact combinatorially. A major goal of modern biology is to provide simple models that predict this complex behavior. The yeast gene RNR1 is transcribed periodically during the cell cycle. Here, we present a pilot study to demonstrate a new method of deciphering the logic behind transcriptional regulation. We took regular samples from cell cycle synchronized cultures of… CONTINUE READING

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