Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

@article{Lim2011ReversalOT,
  title={Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol},
  author={Ee Lin Lim and Kieren G. Hollingsworth and Benjamin S. Aribisala and M. Chen and John Cummings Mathers and R Taylor},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={2506 - 2514}
}
Aims/hypothesisType 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake.MethodsEleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 kg/m2, nine male and two female) were studied before and after 1, 4 and 8 weeks of a 2.5 MJ (600 kcal)/day diet. Basal hepatic glucose output, hepatic and peripheral insulin… 
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Type 2 diabetes and remission: practical management guided by pathophysiology
  • Roy Taylor
  • Medicine
    Journal of internal medicine
  • 2020
TLDR
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Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction
TLDR
Liver triacylglycerol in women with GDM was not elevated, unlike observations in non-pregnant women with a history of GDM, and the underlying pathophysiology of glucose metabolism appeared unchanged.
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