Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

@article{Lim2011ReversalOT,
  title={Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol},
  author={E. Lim and K. Hollingsworth and Benjamin S. Aribisala and M. J. Chen and J. Mathers and R. Taylor},
  journal={Diabetologia},
  year={2011},
  volume={54},
  pages={2506 - 2514}
}
Aims/hypothesisType 2 diabetes is regarded as inevitably progressive, with irreversible beta cell failure. The hypothesis was tested that both beta cell failure and insulin resistance can be reversed by dietary restriction of energy intake.MethodsEleven people with type 2 diabetes (49.5 ± 2.5 years, BMI 33.6 ± 1.2 kg/m2, nine male and two female) were studied before and after 1, 4 and 8 weeks of a 2.5 MJ (600 kcal)/day diet. Basal hepatic glucose output, hepatic and peripheral insulin… Expand
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