Reversal of thromboxane A2/prostaglandin H2 and ADP-induced calcium release in intact platelets.

@article{Brace1985ReversalOT,
  title={Reversal of thromboxane A2/prostaglandin H2 and ADP-induced calcium release in intact platelets.},
  author={Larry D. Brace and Duane L. Venton and Guy C Le Breton},
  journal={The American journal of physiology},
  year={1985},
  volume={249 1 Pt 2},
  pages={H8-13}
}
We previously demonstrated that thromboxane A2 and/or prostaglandin H2 (TXA2/PGH2), ADP, and A23187 cause calcium mobilization in intact human platelets. Other studies have also shown that platelet shape change and aggregation induced by a variety of platelet agonists can be reversed by specific antagonists. In the present study, we used the fluorescent calcium probe chlortetracycline to evaluate whether the reversal of platelet activation involves a resequestration of intraplatelet calcium. It… CONTINUE READING