Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments

@article{Troncone1988ReversalOT,
  title={Reversal of the increase in apomorphine-induced stereotypy and aggression in REM sleep deprived rats by dopamine agonist pretreatments},
  author={Lanfranco Ranieri Paolo Troncone and T. M. S. Ferreira and Sofia Braz and N. G. Silveira Filho and Sergio Brasil Tufik},
  journal={Psychopharmacology},
  year={1988},
  volume={94},
  pages={79-83}
}
REM sleep deprivation (REMSD) induces augmented responses to dopaminergic agonists. Prolonged administration of neuroleptics induces a similar state, probably by the production of supersensitivity of dopaminergic receptors. Such a supersensitive state could be induced by REMSD as a result of impairment of dopamine neurotransmission. In order to test this hypothesis, bromocriptine, nomifensine, amphetamine,l-dopa, imipramine and electroconvulsive shock (ECS) were administered to rats during… CONTINUE READING

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