Reversal of the growth inhibitory effect of α-difluoromethylornithine by putrescine but not by other divalent cations

Abstract

Treatment with α-difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase (ODC), depletes the putrescine and spermidine content, and reduces the growth rate of Ehrlich ascites tumor cells. The addition of putrescine, which is the immediate precursor of spermidine, promptly replenished the intracellular putrescine… (More)
DOI: 10.1007/BF00224773

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@article{Oredsson1984ReversalOT, title={Reversal of the growth inhibitory effect of α-difluoromethylornithine by putrescine but not by other divalent cations}, author={Stina Oredsson and Siw Anehus and Olle Heby}, journal={Molecular and Cellular Biochemistry}, year={1984}, volume={64}, pages={163-172} }