Reversal of the electrocardiographic effects of cocaine by lidocaine. Part 2. Concentration-effect relationships.

@article{Grawe1994ReversalOT,
  title={Reversal of the electrocardiographic effects of cocaine by lidocaine. Part 2. Concentration-effect relationships.},
  author={Johannes Grawe and Robert J Hariman and A P Winecoff and Juergen Hartmut Fischer and Jerry L Bauman},
  journal={Pharmacotherapy},
  year={1994},
  volume={14 6},
  pages={704-11}
}
Ventricular arrhythmias due to cocaine may be related to its ability to slow ventricular conduction or prolong repolarization. We previously showed that lidocaine reversed QRS prolongation due to cocaine. The purposes of these experiments were to characterize cocaine's concentration-effect relationship on both ventricular conduction and repolarization, and to determine the effects of lidocaine on these relationships. The effects of lidocaine on cocaine-induced electrocardiographic changes were… CONTINUE READING

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