Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses.

@article{Hariman1979ReversalOT,
  title={Reversal of the cardiovascular effects of verapamil by calcium and sodium: differences between electrophysiologic and hemodynamic responses.},
  author={Robert J Hariman and Lucia Mangiardi and Russell G Mcallister and Borys Surawicz and Ralph Shabetai and Hiroshi Kishida},
  journal={Circulation},
  year={1979},
  volume={59 4},
  pages={797-804}
}
The reversibility of verapamil-induced hemodynamic and electrophysiologic changes by intravenously administered CaCI2 and NaCI was tested in 34 anesthetized open-chest dogs during verapamil infusions which produced plasma verapamil concentrations of 70-2042 ng/ml. An increase of serum calcium concentration (Ca). to an average 6.5 mEq/l abolished the… CONTINUE READING