Reversal of the TCR Stop Signal by CTLA-4

@article{Schneider2006ReversalOT,
  title={Reversal of the TCR Stop Signal by CTLA-4},
  author={H. Schneider and J. Downey and A. Smith and B. Zinselmeyer and C. Rush and J. Brewer and B. Wei and N. Hogg and P. Garside and C. Rudd},
  journal={Science},
  year={2006},
  volume={313},
  pages={1972 - 1975}
}
  • H. Schneider, J. Downey, +7 authors C. Rudd
  • Published 2006
  • Medicine, Biology
  • Science
  • The coreceptor cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) is pivotal in regulating the threshold of signals during T cell activation, although the underlying mechanism is still not fully understood. Using in vitro migration assays and in vivo two-photon laser scanning microscopy, we showed that CTLA-4 increases T cell motility and overrides the T cell receptor (TCR)–induced stop signal required for stable conjugate formation between T cells and antigen-presenting cells. This event led… CONTINUE READING
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