Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198
@article{Ciccocioppo2002ReversalOS, title={Reversal of stress- and CRF-induced anorexia in rats by the synthetic nociceptin/orphanin FQ receptor agonist, Ro 64-6198}, author={Roberto Ciccocioppo and Michela Biondini and Lorena Antonelli and Juergen Wichmann and François Jenck and Maurizio Massi}, journal={Psychopharmacology}, year={2002}, volume={161}, pages={113-119} }
Abstract.Rationale: (1S,3aS)-8-(2,3,3,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (Ro 64-6198), a non-peptidic agonist for the opioid receptor-like1 (ORL1) receptor, exhibits anxiolytic properties in stressful conditions. Objective: The present study was aimed at evaluating whether activation of ORL1 receptors by Ro 64-6198 may reverse the anorectic effect of restraint stress or intracerebroventricular (ICV) CRF injection. Methods: In body restraint experiments…
73 Citations
Effects of nociceptin/orphanin FQ receptor (NOP) agonist, Ro64-6198, on reactivity to acute pain in mice: comparison to morphine.
- BiologyEuropean journal of pharmacology
- 2008
Distribution of nociceptin and Ro64-6198 activated [35S]-GTPγS binding in the rat brain
- Biology, ChemistryNeuropeptides
- 2006
The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference
- Biology, PsychologyNeuropharmacology
- 2005
The nociceptin/orphanin FQ/NOP receptor system as a target for treatment of alcohol abuse: a review of recent work in alcohol-preferring rats
- BiologyPhysiology & Behavior
- 2003
Nociceptin/orphanin FQ acts as a functional antagonist of corticotropin-releasing factor to inhibit its anorectic effect
- BiologyPhysiology & Behavior
- 2004
Activation of the Nociceptin/Orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat
- Biology, ChemistryPeptides
- 2006
Functional antagonism between nociceptin/orphanin FQ (N/OFQ) and corticotropin-releasing factor (CRF) in the rat brain: evidence for involvement of the bed nucleus of the stria terminalis
- Biology, PsychologyPsychopharmacology
- 2007
Evaluating the role of the BST in the functional antagonism between N/OFQ and CRF by examining it at molecular level and in the context of CRF-induced anxiety in the rat suggests that this antagonism may occur within the BST.
MT-7716, a novel selective nonpeptidergic NOP receptor agonist, effectively blocks ethanol-induced increase in GABAergic transmission in the rat central amygdala
- BiologyFront. Integr. Neurosci.
- 2014
Support is provided for an interaction between the nociceptin and GABAergic systems in the CeA and for the anti-alcohol properties of the NOP activation.
Attenuation of ethanol self-administration and of conditioned reinstatement of alcohol-seeking behaviour by the antiopioid peptide nociceptin/orphanin FQ in alcohol-preferring rats
- Psychology, MedicinePsychopharmacology
- 2004
The present study demonstrates that the reinforcing effects of ethanol are markedly blunted by activation of the opioidergic N/OFQ receptor system, and provides evidence of the efficacy of N/ OFQ to prevent reinstatement of ethanol-seeking behaviour elicited by environmental conditioned stimuli.
The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity.
- BiologyCNS drug reviews
- 2007
Preclinical data indicate that Ro 64-6198 may have broad clinical uses, such as in treating stress and anxiety, addiction, neuropathic pain, cough, and anorexia, and it has subnanomolar affinity for the NOP receptor and is at least 100 times more selective for theNOP receptor over the classic opioid receptors.
References
SHOWING 1-10 OF 48 REFERENCES
A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.
- Biology, PsychologyProceedings of the National Academy of Sciences of the United States of America
- 2000
These data confirm the notable anxiolytic-like effects observed at low doses with the orphanin FQ/nociceptin neuropeptide given locally into the brain and support a role for orphan in F Q/nOCiceptin in adaptive behavioral fear responses to stress.
Nociceptin/orphanin FQ inhibits stress- and CRF-induced anorexia in rats
- Biology, PsychologyNeuroreport
- 2001
Findings provide original evidence that NC attenuates stress-induced anorexia, presumably by acting as a functional CRF antagonist, and suggest that the effect of NC is selective forAnorexia induced by stress or CRF.
The role of CRF2 receptors in corticotropin‐releasing factor‐and urocortin‐induced anorexia
- Biology, PsychologyNeuroreport
- 1998
The data suggest that down-regulation of CRF2 receptors selectively attenuates CRF-and UCN-induced anorexia and hypothalamo-pituitary-adrenocortical activation in rats.
CRF-Deficient Mice Respond Like Wild-Type Mice to Hypophagic Stimuli
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 1999
Verapamil and indomethacin attenuate endotoxin-induced anorexia
- Medicine, BiologyPhysiology & Behavior
- 1989
Effect of nociceptin on alcohol intake in alcohol-preferring rats
- MedicinePsychopharmacology
- 1999
The results of the present study suggest that the brain NC mechanisms may represent an interesting target of pharmacological interventions for the treatment of alcoholism.
Orphanin FQ/nociceptin: a role in pain and analgesia, but so much more
- BiologyTrends in Neurosciences
- 1998
Pharmacological characterization of the nociceptin receptor mediating hyperphagia: identification of a selective antagonist
- BiologyPsychopharmacology
- 2000
The findings suggest that [F/G)]NC(1–13)NH2, which has been reported to act as a NC receptor antagonist in peripheral tissues, be- haves as a full agonist at the central NC receptors controlling feeding, to study the physiological and pathophysiological role of NC in feeding behaviour.
Nociceptin prevents stress‐induced ethanol‐but not cocaine‐seeking behavior in rats
- Biology, PsychologyNeuroreport
- 2000
The hypothesis that the NC system participates in the regulation of behavioral responses to stress, and that drugs interacting with NC receptors may have therapeutic potential for the treatment of stress-induced alcohol-seeking behavior and relapse, is supported.