Reversal of stable behavioural modifications through NMDA receptor inhibition in rats.

@article{Montis1995ReversalOS,
  title={Reversal of stable behavioural modifications through NMDA receptor inhibition in rats.},
  author={M Graziella De Montis and Carla Gambarana and Ombretta Ghiglieri and Alessandro Tagliamonte},
  journal={Behavioural pharmacology},
  year={1995},
  volume={6 5 And 6},
  pages={562-567}
}
In order to study the effect of long-term dizocilpine infusion on memory, two different paradigms of stably modified behaviour were used in rats. The first was the escape deficits (ED) induced and maintained either by repeated daily administrations of SKF 38393, a rather selective D1 dopamine receptor agonist, or by repeated stress; the second was sensitisation to the effect of cocaine on motility. Fluoxetine (FLX), imipramine (IMI) and clomipramine (CMI) were equally effective in reversing the… CONTINUE READING