Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.

@article{Fischer1994ReversalOS,
  title={Reversal of spatial memory impairments in aged rats by nerve growth factor and neurotrophins 3 and 4/5 but not by brain-derived neurotrophic factor.},
  author={Walter M. Fischer and A M Sirevaag and Stanley J. Wiegand and Ronald M. Lindsay and Anders Bj{\"o}rklund},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 18},
  pages={8607-11}
}
Aged rats, displaying impairments in spatial learning and memory associated with marked cellular atrophy of forebrain cholinergic neurons, received intracerebroventricular infusions of one of the four neurotrophins nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), or neurotrophin 4/5 (NT-4/5), or a combination of NGF and BDNF, or vehicle. During the 4-week infusion period rats receiving NGF, NT-3, or NT-4/5 showed improved acquisition and retention of… CONTINUE READING