Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults.

@article{Hersh2008ReversalOS,
  title={Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults.},
  author={E. Hersh and P. Moore and A. Papas and J. M. Goodson and L. Navalta and S. Rogy and B. Rutherford and J. Yagiela},
  journal={Journal of the American Dental Association},
  year={2008},
  volume={139 8},
  pages={
          1080-93
        }
}
  • E. Hersh, P. Moore, +5 authors J. Yagiela
  • Published 2008
  • Medicine
  • Journal of the American Dental Association
  • BACKGROUND The authors conducted two multicenter, randomized, double-blinded, controlled Phase III clinical trials to study the efficacy and safety of phentolamine mesylate (PM) in shortening the duration and burden of soft-tissue anesthesia. The study involved 484 subjects who received one of four commercially available local anesthetic solutions containing vasoconstrictors for restorative or scaling procedures. METHODS On completion of the dental procedure, subjects randomly received a PM… CONTINUE READING
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    Topics from this paper

    Paper Mentions

    Interventional Clinical Trial
    Oraverse © (Phentolamine mesylate) is a product designed to reverse the effect of local anesthetics used in dentistry. Its main objective is to reduce the postoperative period… Expand
    ConditionsAnesthesia, Local
    InterventionDrug
    Interventional Clinical Trial
    The purpose of this study is to determine whether OraVerse is safe and effective for the reversal of dental anesthesia in children 2 to 5 years of age weighing at least 10 kg.  
    ConditionsAnesthesia, Local, Anesthesia, Reversal, Dental Anesthesia
    InterventionDrug, Other
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