• Medicine
• Published in
  Journal of the American…
  2008
• DOI:10.14219/jada.archive.2008.0311

Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults.

@article{Hersh2008ReversalOS,
  title={Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults.},
  author={Elliot V. Hersh and Paul A. Moore and Athena S. Papas and Jo Max Goodson and Laura A Navalta and Siegfried Rogy and Bruce Rutherford and John A. Yagiela},
  journal={Journal of the American Dental Association},
  year={2008},
  volume={139 8},
  pages={
          1080-93
        }
}

• Elliot V. Hersh, Paul A. Moore, +5 authors John A. Yagiela

BACKGROUND The authors conducted two multicenter, randomized, double-blinded, controlled Phase III clinical trials to study the efficacy and safety of phentolamine mesylate (PM) in shortening the duration and burden of soft-tissue anesthesia. The study involved 484 subjects who received one of four commercially available local anesthetic solutions containing vasoconstrictors for restorative or scaling procedures. METHODS On completion of the dental procedure, subjects randomly received a PM… CONTINUE READING

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