Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults.
@article{Hersh2008ReversalOS, title={Reversal of soft-tissue local anesthesia with phentolamine mesylate in adolescents and adults.}, author={E. Hersh and P. Moore and A. Papas and J. M. Goodson and L. Navalta and S. Rogy and B. Rutherford and J. Yagiela}, journal={Journal of the American Dental Association}, year={2008}, volume={139 8}, pages={ 1080-93 } }
BACKGROUND
The authors conducted two multicenter, randomized, double-blinded, controlled Phase III clinical trials to study the efficacy and safety of phentolamine mesylate (PM) in shortening the duration and burden of soft-tissue anesthesia. The study involved 484 subjects who received one of four commercially available local anesthetic solutions containing vasoconstrictors for restorative or scaling procedures.
METHODS
On completion of the dental procedure, subjects randomly received a PM… CONTINUE READING
Topics from this paper
Paper Mentions
Interventional Clinical Trial
Oraverse © (Phentolamine mesylate) is a product designed to reverse the effect of local
anesthetics used in dentistry. Its main objective is to reduce the postoperative period… Expand
Conditions | Anesthesia, Local |
---|---|
Intervention | Drug |
Interventional Clinical Trial
The purpose of this study is to determine whether OraVerse is safe and effective for the
reversal of dental anesthesia in children 2 to 5 years of age weighing at least 10 kg.
Conditions | Anesthesia, Local, Anesthesia, Reversal, Dental Anesthesia |
---|---|
Intervention | Drug, Other |
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