Reversal of severe methotrexate-induced intestinal damage using enteral n-3 fatty acids.

Abstract

Growing evidence suggests that n-3 PUFA and their specific lipid mediators can reduce the activity of inflammatory processes. In the present study, we evaluated the effects of oral n-3 PUFA supplementation on intestinal structural changes, enterocyte proliferation and apoptosis during methotrexate (MTX)-induced intestinal damage in the rat. A total of… (More)
DOI: 10.1017/S0007114512000542

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