Reversal of reserpine-induced orofacial dyskinesia and cognitive dysfunction by quercetin.

@article{Naidu2004ReversalOR,
  title={Reversal of reserpine-induced orofacial dyskinesia and cognitive dysfunction by quercetin.},
  author={P. S. Naidu and Damanpreet Singh and Shrinivas Krishnarao Kulkarni},
  journal={Pharmacology},
  year={2004},
  volume={70 2},
  pages={
          59-67
        }
}
Tardive dyskinesia (TD) is a serious neurological syndrome associated with long-term administration of neuroleptics to humans and experimental animals. The pathophysiology of this disabling and commonly irreversible movement disorder is still obscure. It may be caused by a loss of dopaminergic cells or may be due to free radicals as a product of high synaptic dopamine levels. Quercetin is a bioflavonoid with strong antioxidant properties. Repeated treatment with reserpine (1.0 mg/kg) on each… CONTINUE READING
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