Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin.

@article{Ruch1993ReversalOR,
  title={Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin.},
  author={Randall J. Ruch and Burra V. Madhukar and James Edward Trosko and James E Klaunig},
  journal={Molecular carcinogenesis},
  year={1993},
  volume={7 1},
  pages={50-9}
}
The plasma-membrane association and transforming activity of the ras oncoprotein p21 are dependent upon posttranslational farnesylation. Farnesyl synthesis and p21 ras farnesylation are inhibited by hydroxymethylglutaryl-CoA reductase inhibitors such as lovastatin. In this study, we examined whether lovastatin could reverse the transformed phenotype of a v-Ha-ras-transformed rat liver epithelial cell line (WB-ras cells) and if changes were associated with the enhancement of gap-junctional… CONTINUE READING

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