Reversal of peptide backbone direction may result in the mirroring of protein structure.

@article{Guptasarma1992ReversalOP,
  title={Reversal of peptide backbone direction may result in the mirroring of protein structure.},
  author={Purnananda Guptasarma},
  journal={FEBS letters},
  year={1992},
  volume={310 3},
  pages={205-10}
}
In linear polypeptides, inversion of amino acid chirality (all-L to all-D) achieves a mirroring of side chain positions and interactions in conformational space. A similar mirroring of side chain positions is independently achieved by a reversal of the direction of the peptide backbone (retro modification). Thus, while an all-D chain could be expected to… CONTINUE READING