Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator.

@article{Hurt2006ReversalOP,
  title={Reversal of p53 epigenetic silencing in multiple myeloma permits apoptosis by a p53 activator.},
  author={Elaine M. Hurt and Suneetha Betsy Thomas and Benjamin Peng and William L. Farrar},
  journal={Cancer biology & therapy},
  year={2006},
  volume={5 9},
  pages={1154-60}
}
Inactivation of the p53 pathway is a common feature of neoplasia. Dysregulation of the p53 pathway has been shown to involve mutations of p53, increased expression of the p53 inhibitor HDM-2, or epigenetic silencing of the p53 promoter. In multiple myeloma, a neoplasia of terminally differentiated B cells, p53 mutations and deletions are relatively rare and occur in late stage disease. Here, we show that the p53 promoter is hypermethylated in several multiple myeloma cell lines in comparison to… CONTINUE READING
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