Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene.

@article{Tanaka1985ReversalOO,
  title={Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene.},
  author={Kenichi Tanaka and Kurt J Isselbacher and George F. El Khoury and Gilbert Jay},
  journal={Science},
  year={1985},
  volume={228 4695},
  pages={
          26-30
        }
}
The classical transplantation antigens (the major histocompatibility complex class I antigens) play a key role in host defense against cells expressing foreign antigens. Several naturally occurring tumors and virally transformed cells show an overall suppression of these surface antigens. Since the class I molecules are required in the presentation of neoantigens on tumor cells to the cytotoxic T lymphocytes, their absence from the cell surface may lead to the escape of these tumors from… CONTINUE READING

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