Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.

@article{Storkus1989ReversalON,
  title={Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes.},
  author={Walter J. Storkus and Jeff Alexander and John A. Payne and Jeffrey R. Dawson and Peter Cresswell},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1989},
  volume={86 7},
  pages={2361-4}
}
A number of studies have suggested that resistance of target cells to natural killing (NK) may be correlated with their level of expression of major histocompatibility complex (MHC) class I antigens. To examine this hypothesis directly, a NK-sensitive class I-deficient human B-cell line was transfected with MHC class I genes. The expression of transfected HLA, but not H-2, class I gene products resulted in loss of susceptibility to human NK-mediated conjugation and cytolysis. Furthermore, this… CONTINUE READING