Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.

@article{Liu2004ReversalOM,
  title={Reversal of mutant myocilin non-secretion and cell killing: implications for glaucoma.},
  author={Yuhui Liu and Douglas Vollrath},
  journal={Human molecular genetics},
  year={2004},
  volume={13 11},
  pages={1193-204}
}
Glaucoma is a progressive blinding disease characterized by gradual loss of vision due to optic neuropathy and retinal ganglion cell death. Increased intraocular pressure is a common feature of glaucoma that is thought to arise from an increased resistance to outflow of aqueous humor through the trabecular meshwork. Mutations of the myocilin gene are one cause of autosomal dominant juvenile- and adult-onset primary open angle glaucoma, but the mechanism by which mutant myocilins cause disease… CONTINUE READING
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