Reversal of multidrug resistance phenotype in human breast cancer cells using doxorubicin-liposome-microbubble complexes assisted by ultrasound.

@article{Deng2014ReversalOM,
  title={Reversal of multidrug resistance phenotype in human breast cancer cells using doxorubicin-liposome-microbubble complexes assisted by ultrasound.},
  author={Zhiting Deng and Fei Yan and Qiaofeng Jin and Fei Li and Junru Wu and Xin Liu and Hairong Zheng},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2014},
  volume={174},
  pages={
          109-16
        }
}
The circumvention of multidrug resistance (MDR) plays a critically important role in the success of chemotherapy. The aim of this work is to investigate the effectiveness and possible mechanisms of the reversal of MDR phenotype in human breast cancer cells by using doxorubicin-liposome-microbubble complexes (DLMC) assisted by ultrasound (US). DLMC is fabricated through conjugating doxorubicin (DOX)-liposome (DL) to the surface of microbubbles (MBs) via the biotin-avidin linkage. The resulting… CONTINUE READING
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