Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol.

@article{Christensen1996ReversalOM,
  title={Reversal of multidrug resistance in vivo by dietary administration of the phytochemical indole-3-carbinol.},
  author={Jmes G Christensen and Gerald A. LeBlanc},
  journal={Cancer research},
  year={1996},
  volume={56 3},
  pages={574-81}
}
A major obstacle to successful chemotherapy is the development of multidrug resistance (MDR) by cancer cells. MDR is characterized by enhanced cellular efflux of many structurally and functionally diverse compounds, including many anticancer drugs, due to overexpression of the MDR-1 gene product, P-glycoprotein. We hypothesized that the phytochemical, indole-3-carbinol (I3C), and some of its acid-condensation derivatives may inhibit P-glycoprotein-mediated transport due to their aromatic and… CONTINUE READING