Reversal of multidrug resistance by tyrosine‐kinase inhibitors in a non‐P‐glycoprotein‐mediated multidrug‐resistant cell line

@article{Takeda1994ReversalOM,
  title={Reversal of multidrug resistance by tyrosine‐kinase inhibitors in a non‐P‐glycoprotein‐mediated multidrug‐resistant cell line},
  author={Y. Takeda and Kazuto Nishio and H. Niitani and Nagahiro Sajio},
  journal={International Journal of Cancer},
  year={1994},
  volume={57}
}
  • Y. Takeda, Kazuto Nishio, +1 author Nagahiro Sajio
  • Published 1994
  • Biology, Medicine
  • International Journal of Cancer
  • We have already established a human leukemia sub‐line resistant to the growth‐inhibitory effect of TPA (12‐O‐tetradecanoylphorbol 13‐acetate) (K562/TPA) derived from K562. KS62/TPA was found to be a non‐P‐glycoprotein‐mediated multidrug‐ resistant cell line, in which intracellular drug accumulation was not reduced. In K562/TPA, adriamycin (ADM) was distributed mainly in the cytoplasm and was scarcely observed in the nucleus. We determined the relative levels of multidrug‐resistance‐associated… CONTINUE READING
    Protein kinases and multidrug resistance
    • 17

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