Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells.

@article{Stein1996ReversalOM,
  title={Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells.},
  author={Ulrike Stein and W. Walther and Robert H. Shoemaker},
  journal={Journal of the National Cancer Institute},
  year={1996},
  volume={88 19},
  pages={1383-92}
}
BACKGROUND Multidrug resistance can be a major obstacle to successful cancer chemotherapy and is often associated with increased expression of the mdr1 (also known as P-glycoprotein) gene. Some of the proteins produced by the body's immune system, i.e., cytokines such as tumor necrosis factor-alpha (TNF) and interleukin 2 (IL-2), have been shown to modulate multidrug resistance. However, cytokines administered by the conventional intravenous method can cause severe side effects. Transduction of… CONTINUE READING