Reversal of multidrug resistance by the staurosporine derivatives CGP 41251 and CGP 42700.

@article{Utz1998ReversalOM,
  title={Reversal of multidrug resistance by the staurosporine derivatives CGP 41251 and CGP 42700.},
  author={Irene Utz and Martin Spitaler and Maria Rybczyńska and C. Ludescher and Wolfgang Hilbe and Urs Regenass and Hans H. Grunicke and Johann Hofmann},
  journal={International journal of cancer},
  year={1998},
  volume={77 1},
  pages={64-9}
}
It has been shown previously that the staurosporine derivative CGP 41251, a specific inhibitor of protein kinase C (IC50 = 50 nM), exhibits antitumor activity and reverses mdr1 mediated multidrug resistance. At present, the compound is evaluated as an anticancer drug in clinical phase I trials. We compared the effects of CGP 41251 with CGP 42700, another… CONTINUE READING