Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R

@article{Xiao2009ReversalOM,
  title={Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R},
  author={Hui Xiao and Qi Xiao and Kejian Zhang and Xuelan Zuo and Umid Kumar Shrestha},
  journal={Annals of Hematology},
  year={2009},
  volume={89},
  pages={399-404}
}
Most patients with multiple myeloma (MM) will relapse eventually due to the acquired multidrug resistance (MDR). The objective of this study was to explore the reversal effect of curcumin on the MDR of human MM cell line, MOLP-2/R, and analyze the role of Fanconi anemia (FA)/BRCA pathway in this process. MOLP-2/R was selected by stepwise exposure of parental MOLP-2 cells to increasing concentrations of melphalan. The MTT assay was used to detect the reversal ratio of curcumin. The FANCD2… CONTINUE READING
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